Nov 10, 2017
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POTASSIUM BROMIDE (KBr) : SEIZURES/EPILEPSY IN DOGS

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Epilepsy is most common neurological disorder in dogs. There can be a number of reasons for this condition from heavy worm infestation, canine distemper infection, toxicity, trauma to the idiopathic or familial cause. There has been a lot of advancement and newer therapies are being tried for managing this disease.

Potassium Bromide is now the first choice for managing epilepsy in dogs. It is the only salt used for epilepsy management without any side effect on the liver and all other adverse effects from Kbr are completely reversible once treatment is discontinued. KBr is effective in almost 90% of epilepsy cases and is even effective in cases that do not respond to Phenobarbital. Often KBr and Phenobarbital are used together to control 98% of epileptic cases. KBr and Phenobarbital combination allows reducing the dose of Phenobarbital and even completely replace it later.

Dosage:

Another advantage of KBr is its flexibility of dosage. The dose can be given once a day or twice a day. Even if you missed some doses you can compensate it later without any side effects.

The dosage of Potassium Bromide is calculated and adjusted regularly to achieve a target blood concentration of 2 to 3 mg/ml if no Phenobarbital is used and 1-1.5 mg/ml if Phenobarbital is also used.

To achieve this usually daily dose should be 20-30 mg/kg body weight. It takes 2-3 weeks to reach the therapeutic range with this dosage. In severe cases where rapid maintenance is needed a’ loading dose,’ 400-600 mg/kg can be given for 4-5 days before maintaining therapeutic blood level.

Adverse effect:

Although very rare few adverse effects  are:

  1. Ataxia
  2. Vomiting
  3. Excessive Urination
  4. Irritability

The symptom is mostly due to increase in the concentration of KBr in blood and require a little reduction in dose.

Cautions:

KBr is eliminated through Kidney, so it should be used cautiously in Kidney diseases.

Also use cautiously in pregnant animals and cats.

Epilepsy is most common neurological disorder in dogs. There can be a number of reasons for this condition from heavy worm infestation, canine distemper infection, toxicity, trauma to the idiopathic or familial cause. There has been a lot of advancement and newer therapies are being tried for managing this disease. Potassium Bromide is now the first choice for managing epilepsy in dogs. It is the only salt used for epilepsy management without any side effect on the liver and all other adverse effects from Kbr are completely reversible once treatment is discontinued. KBr is effective in almost 90% of epilepsy cases and is even effective in cases that do not respond to Phenobarbital. Often KBr and Phenobarbital are used together to control 98% of epileptic cases. KBr and Phenobarbital combination allows reducing the dose of Phenobarbital and even completely replace it later. Dosage: Another advantage of KBr is its flexibility of dosage. The dose can be given once a day or twice a day. Even if you missed some doses you can compensate it later without any side effects. The dosage of Potassium Bromide is calculated and adjusted regularly to achieve a target blood concentration of 2 to 3 mg/ml if no Phenobarbital is used and 1-1.5 mg/ml if Phenobarbital is also used. To achieve this usually daily dose should be 20-30 mg/kg body weight. It takes 2-3 weeks to reach the therapeutic range with this dosage. In severe cases where rapid maintenance is needed a’ loading dose,’ 400-600 mg/kg can be given for 4-5 days before maintaining therapeutic blood level. Adverse effect: Although very rare few adverse effects  are: Ataxia Vomiting Excessive Urination Irritability The symptom is mostly due to increase in the concentration of KBr in blood and require a little reduction in dose. Cautions: KBr is eliminated through Kidney, so it should be used cautiously in Kidney diseases. Also use cautiously in pregnant animals and cats.

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